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We did a population based matched cohort study based on routinely and prospectively collected data from Danish administrative and medical registries (catchment dynamic population about six million inhabitants).20 A national health insurance programme ensures tax supported healthcare for the entire Danish population.

The unique civil registration number, assigned to all Danish residents at birth or immigration, allows exact linkage of data from all registries, after which data are anonymised.20 The registries capture dispensings from outpatient pharmacies prescribed by general practitioners but do not capture diagnoses or other clinical data from general practice.

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No meaningful association was found with peripheral artery disease (adjusted hazard ratio 1.12, 0.96 to 1.30) or heart failure (1.04, 0.93 to 1.16).

The incident outcomes included myocardial infarction, ischaemic and haemorrhagic stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure and were ascertained using all available inpatient and outpatient diagnoses recorded in the DNPR.In a subcohort of patients, the associations persisted after additional multivariable adjustment for body mass index and smoking.Conclusions Migraine was associated with increased risks of myocardial infarction, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, and atrial fibrillation or atrial flutter.After 19 years of follow-up, the cumulative incidences per 1000 people for the migraine cohort compared with the general population were 25 18 for heart failure.Correspondingly, migraine was positively associated with myocardial infarction (adjusted hazard ratio 1.49, 95% confidence interval 1.36 to 1.64), ischaemic stroke (2.26, 2.11 to 2.41), and haemorrhagic stroke (1.94, 1.68 to 2.23), as well as venous thromboembolism (1.59, 1.45 to 1.74) and atrial fibrillation or atrial flutter (1.25, 1.16 to 1.36).To examine the underlying mechanism, we separately analysed the risk of deep vein thrombosis, pulmonary embolism, provoked venous thromboembolism (defined on the basis of a diagnosis of malignancy any time before the venous thromboembolism diagnosis, or pregnancy, trauma, or surgery 90 days before the diagnosis), and unprovoked venous thromboembolism.