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Most HPV infections of the cervix are cleared rapidly by the immune system and do not progress to cervical cancer (see below the Clearance subsection in Virology).

A large increase in the incidence of genital HPV infection occurs at the age when individuals begin to engage in sexual activity.

Studies have also shown a link between a wide range of HPV types and squamous cell carcinoma of the skin.

In such cases, in vitro studies suggest that the E6 protein of the HPV virus may inhibit apoptosis induced by ultraviolet light.

E6 also has a close relationship with the cellular protein E6-associated protein (E6-AP), which is involved in the ubiquitin ligase pathway, a system that acts to degrade proteins.

E6-AP binds ubiquitin to the p53 protein, thereby flagging it for proteosomal degradation.